RESUMO
in order to determine the effect of maternal exercise on maternal nutritional status and fetal growth, young (Y=45-50 days old) Wistar rats were divided into 4 groups of 5 to 8 animals: control pregnant (CP), control non-pregnant (CNP), exercise-trained (swimming 1 j/day, 5 days/week, for 19 days) pregnant (TP) and exercise trained non-pregnant (TNP). Four equivalent groups of adult rats (A=90-100 days old) were also formed. Serum glucose, total protein, albumin, hematocrit and liver glycogen were determined in female rats and pups. There were no statistical differences in serum glucose, total protein and albumin levels, litter size or birth weight among exercise-trained animals, controls and their respective pups. Hematocrit was significantly lower in pups of exercise-trained young and control rats of the same age and physiological status (YCNP+4.1 ñ 0.2; YCP = 2.7 ñ 0.9; YTNP + 4.9 ñ 0.8; YTP = 2.7 ñ 0.4; ACNP = 6.1 ñ 0.6; ACP = 3.1 ñ 0.8; ATNP = 6.6 ñ 0.8; ATP = 2.2 ñ 0.9 mg/100 mg). We conclude that pups of adult female rats are spared from the effects of this kind of exercise training during pregnancy. On the other hand, it appears that maternal adaptations to exercise training in young rats are able to preserve only some aspects of pup metabolism
Assuntos
Gravidez , Sangue Fetal/análise , Feto/crescimento & desenvolvimento , Homeostase , Movimento/efeitos adversosRESUMO
Hypoglycin B, a toxic hypoglycaemic constituent contained in the seed of the plant, Blighia sapida, is highly teratogenic in the rat when administering intra-amniotically on day 14 of gestation. Major foetal abnormalities comprise malformations of the cranio-facial region and of the limbs. (summary)
Assuntos
Ratos , 21003 , Feminino , Anormalidades Induzidas por Medicamentos/epidemiologia , Feto/crescimento & desenvolvimento , Nozes , Propionatos/efeitos adversos , Aminoácidos/administração & dosagem , Aminoácidos/efeitos adversos , Âmnio/efeitos dos fármacos , Feto/efeitos dos fármacos , Extratos Vegetais/administração & dosagem , Extratos Vegetais/efeitos adversos , Plantas , Gravidez , Propionatos/administração & dosagemRESUMO
Hypoglycin-A does exert a deleterious effect on the embryo of the rabbit. The most consistently observed disorders of the offspring of dams receiving the substance were a high incidence of foetal resorption and overall stunting of development (AU)
